Background: The successful completion of clinical trials ultimately depends on realistic recruitment predictions.Statistical methods for recruitment prediction implemented in a free-of-charge open-source software could be routinely used by researchers worldwide to design clinical trials.However, the availability of such software implementations is
The environment in which the decision-making process takes place is often characterized by uncertainty and vagueness and, because of that, sometimes it is very hard to express the criteria weights with crisp numbers.Therefore, the application of the Grey System Theory, i.e., grey numbers, in this case, is very convenient when it comes to determinat
Rice (Oryza sativa L.) chalkiness greatly reduces the rice quality and the commercial value.In this study, qWCR4, a previously reported quantitative trait locus (QTL) of white-core rate (WCR), was confirmed by a BC5F2 segregation population and further fine mapped to a 35.26 kb region.In the qWCR4 region, LOC_Os04g50060 and LOC_Os04g50070 showed si
The highly potent botulinum neurotoxin serotype A (BoNT/A) inhibits neurotransmitter release at neuromuscular junctions resulting in flaccid muscle paralysis, respiratory arrest and death.In order to reach their neuronal cell targets, BoNT/A must cross epithelial cell barriers lining the intestines and airways.The toxin is produced as a large prote
Tendons are transition tissues that transfer the contractile forces generated by the muscles to the bones, allowing movement.The region where the tendon attaches to the bone is called bone-tendon junction or enthesis and may be classified as fibrous or fibrocartilaginous.This study aims to analyze the collagen fibers and the cells present in the bo